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There is now extensive evidence demonstrating that there is a gap between the health care that patients receive and the practice that is recommended. In both primary and secondary care there are unwarranted variations in practice and in resulting outcomes that cannot be explained by the characteristics o...

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Clinical research has led to spectacular developments in health care. It has provided us with knowledge about how to prevent diseases, like heart disease, how to reduce the consequences of disease, such as complications of diabetes, and to alleviate symptoms, such as those of lung disease, and how to reh...

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